Amphimedon chloros
Taxonomy
This page represents the following TreeOfLife-200M taxonomic path.[1]
- Kingdom: Animalia
- Phylum: Porifera
- Class: Demospongiae
- Order: Haplosclerida
- Family: Niphatidae
- Genus: Amphimedon
- Species: Amphimedon chloros
Visual Description
Specimen images of Amphimedon chloros in museum collections are available via GBIF/Naturalis, showing preserved sponge material (invertebrate zoology museum specimens).[2]
Biology and human relevance (selected from literature)
A study investigating an ethyl acetate extract of Amphimedon chloros reported 14 identified compounds via LC–MS profiling, including zamamidine (11.4%) and keramamine (10.2%).[3]
In vitro assays used MDA-MB-231 breast cancer cells with human periodontal ligament fibroblasts as a non-cancer control. The extract showed cytotoxicity against MDA-MB-231 with an IC₅₀ of 3.0 µg/mL, while fibroblast viability was largely unaffected in the 50–200 µg/mL range tested.[3]
The same work reported gene-expression changes in MDA-MB-231 consistent with increased apoptosis/cell-cycle regulation: Bax, p21, and caspase-3 upregulated, with Bcl2 and Cyclin D (Cyclin D1) downregulated, and pathway-level discussion involving PI3K/Akt and MAPK signaling as potential upstream regulators (within the study’s experimental context).[3]
Gallery
References
- ↑ Dataset view for Animalia / Porifera / Demospongiae / Haplosclerida / Niphatidae / Amphimedon / chloros constructed from imageomics/TreeOfLife-200M records under this taxonomic path. Hugging Face Datasets. https://huggingface.co/datasets/imageomics/TreeOfLife-200M.
- ↑ Amphimedon chloros Ilan, Gugel & van Soest, 2004. GBIF. https://www.gbif.org/species/2245357. Accessed 2026-07-09.
- 1 2 3 Lamees M. Qasqas; Khaled Khleifat; Khalid A Shadid; Haitham Qaralleh; Moath Alqaraleh. The Impact of Amphimedon chloros Ethyl Acetate Extract on MDA-MB-231 Cell Lines' Expression of Bax, Cyclin D, Caspase 3, P21, C-myc, and Bcl2: Mechanism of inhibition of the Growth of Cancer Cells. Tropical Journal of Natural Product Research. 2024. https://doi.org/10.26538/tjnpr/v8i9.9.